ABSTRACT
We demonstrated rapid detection of SARS-CoV-2 nucleocapsid protein antigen by dual-comb biosensing with surface modification of its corresponding antibody. A sensitivity close to that of RT-PCR was achieved, thanks to the use of active-dummy temperature compensation. © Optica Publishing Group 2022, © 2022 The Author(s)
ABSTRACT
Point-of-care (POC) testing devices are necessary to improve human life with many aspects both for developing and developed countries. Especially, the specific biomolecules, which are related to particular diseases, are the important targets for POC testing. Recently, many researchers are able to develop POC devices in various platforms and designs due to the discovery and development of new advanced technologies. In this review, recent developments of the POC devices for detecting biomolecules in each POC platform have been reviewed with the recent development strategies for detecting biomolecule with their advantages and challenges. The case study of the development of POC devices with the strategies for the new pandemic, Covid-19 has also been reviewed. Finally, the challenges and perspectives on the future advances of the POC for biomolecules are discussed. © 2020 Elsevier B.V.